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4:25 PM UPDATE: LA-169 just reopened. 

LA-169 is shut down from Greenwood all the way to South Lakeshore as Caddo Sheriff's deputies work a major crash involving a train and an 18-wheeler, said Sheriff Steve Prator.

Deputies responded to the call at approximately 11:19 a.m. on Friday. The crash happened on LA-169 by McGee Rd.

Two Union Pacific Railroad crew members have been taken to an area hospital. The driver of the truck was not injured.